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Mounjaro: New weight loss drug approved for use in Britain to be available ‘within weeks’ | UK News

An American weight loss drug approved in a four-dose injection pen format for use in Britain could be available “within weeks”.

Mounjaro, also known as tirzepatide, is a diabetes drug that was authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) to help obese and overweight adults lose and manage weight in November last year.

The authorisation of the US pharmaceutical company Eli Lilly’s Mounjaro “KwikPen” means the company will be able to “begin supply to the UK within weeks”, according to its president and general manager of UK and Northern Europe Laura Steele.

The Mounjaro KwikPen gives four doses of the drug for once-a-week treatment over a month, and has been approved to treat adults with type 2 diabetes and for weight management in obese adults, as well as overweight adult patients who have weight-related health problems like prediabetes, high blood pressure, high cholesterol, or heart problems.

Julian Beach, MHRA interim executive director of healthcare quality and access, said: “The public health importance of safe and effective treatments to help manage diabetes and obesity, which can have a significant impact on people’s health, is clear.

“This approval enables access to the approved Mounjaro pen in a more convenient presentation of a month’s treatment, of one dose per week.”

The jab was approved for NHS use in September last year by the National Institute for Health and Care Excellence (NICE) as an option for patients with type 2 diabetes who do not have the condition under control, but NICE has yet to approve use of the drug for obesity.

The active ingredient in the drug helps to reduce sugar levels in people with type 2 diabetes when their levels are high, and works as a weight management drug by making a patient feel full, and making them experience fewer food cravings.

The MHRA’s newest authorisation is based on the results of a bridging study which showed the efficacy and safety of the multidose Mounjaro KwikPen are expected to be the same as those for the single-dose pen.

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Douglas Twenefour, head of care at Diabetes UK, said: “We hope the MHRA’s approval of this device will help people living with type 2 diabetes, who are eligible, to access this effective treatment.

“Supporting people with type 2 diabetes to lose weight and manage their blood sugar levels is key to reducing the risk of diabetes-related complications, and tirzepatide (Mounjaro) expands the range of treatment options available to help people achieve this.”

However, the MHRA warned Mounjaro may affect how well the contraceptive pill works in obese or overweight female patients.

It also listed potential side effects of the medicine, including nausea, diarrhoea, vomiting – which usually goes away over time – and constipation.

Low blood sugar is also “very common” in patients with diabetes, the agency added.

The MHRA said it will keep the safety and effectiveness of Mounjaro under close review.

Queen ‘approved threatening News International with legal action’ | UK News

Prince Harry’s legal team have listed 208 articles about him in The Sun and the now-defunct News Of The World which his lawyers claim were as a result of private information being unlawfully gathered.

The stories’ headlines and reporters’ names were included in court documents as part of a legal action by the Duke of Sussex, who is suing the publications’ owners – News Group Newspapers (NGN) – over alleged phone hacking, including listening to private voicemail messages.

NGN is bringing a bid to have Harry’s case thrown out, along with a similar claim by actor Hugh Grant, at a three-day hearing in London which started on Tuesday, arguing they have been brought too late.

Pic: AP
Prince Harry pictured at the Royal Courts of Justice in March. Pic: AP

The court documents show:

• A transcript of an alleged intercepted phone message in 2006 from his brother Prince William to Harry claiming to be his former girlfriend Chelsy Davy

• Harry said in a February 2018 email to Buckingham Palace that an apparent lack of response by the newspapers’ publishers – formerly known as News International – over phone hacking claims was making the “institution” [Royal Family] look “ineffective and weak”

• Harry questioned if News International journalists should be allowed “into Windsor” [Castle] for his wedding to Meghan Markle in May 2018 “if it isn’t resolved”

• Harry said “there needs to be an ultimatum otherwise this institution and everything it stands for becomes a laughing stock”

• Another email from the palace said the Queen approved threatening News International with legal action

• The prince’s lawyers claim Harry has “suffered considerable distress, as well as the loss of his dignity or standing, and his personal autonomy, as a result of the misuse of his private information by NGN”

Growing frustration of Harry laid bare in court documents

We’ve heard Prince Harry’s arguments, now we’ve seen his evidence. The Duke of Sussex has publicly released private emails, from those at the heart of the late Queen’s household.

Reading the email trail between Harry and the palace, you get a sense of his growing frustration.

He wants an apology, and the emails show the Queen gives her consent to threatening tabloid executives with legal action.

But still nothing happens, and in the following months there is a significant shift. Despite the Queen consenting to using lawyers, Harry’s father tells him to drop all his claims.

Harry claims this is to prioritise positive stories about him and Camilla. It’s something we’ve heard Harry talk about before.

In his memoir, Spare, Harry says he was sacrificed on Camilla’s “personal PR altar”.

He also recalls how his father, describes his battle with the press as a “suicide mission”.

We now know Prince William settled, out of court, his phone hacking case with the publishers of The Sun and News of the World.

But what we’re seeing with Harry is the opposite. He wants his day in court, he wants to hold senior executives to account. And he’s prepared to say and show as much as he can to expose what he alleges is their “criminal activity”.

According to the court documents, the first of the 208 articles was published on 6 January 1996 and was headlined “Diana: I’ll take my time Ma’am; Exclusive!”

Harry’s lawyers claim it contained private information about the prince’s “personal life and in particular, his health and details of a skiing accident”.

Also included are articles about his “education and professional life” and “details about his relationship with Chelsy Davy”.

Harry's former girlfriend Chelsea Davy pictured in 2011
Harry’s former girlfriend Chelsy Davy pictured in 2011

The 208th article listed was published by The Sun on 1 November 2016 and was headlined “Smitten Harry bombarded Meghan with texts until he got a date”.

His lawyers claim the story contained private information concerning his “personal life and in particular the fact that he had ‘inundated’ and ‘besieged’ Ms Markle with text messages and also details of and the frequency of their dates”.

Harry email
In February 2018, Harry sent an email to the-then palace communications director Sally Osman about the hacking claims against News International
When Ms Osman replied there had been no response, he said the ‘institution’ was looking ‘ineffective and weak’
A month later, Ms Osman emailed to say she had the Queen’s consent to use legal action

In the 2006 William phone message to his brother, a male speaker puts on a female voice, lapsing into normal voice.

The male speaker says: “Hi, it’s Chelsy here. I just want to say I miss you so much, and I think you’re the most – best-looking ginger I’ve ever seen – although you really are quite ugly for a ginger, but hope you’re having a lovely time – I really miss you. It’s lovely out here in Africa, and hopefully I’ll see you very soon, you big, hairy fat ginger. Anyway, speak to you later. Bye.”

According to Harry’s lawyers, the audio transcript of the voicemail was seized from a private investigator’s home.

His legal team claimed around that time there had been a number of suspicious calls from the investigator to Harry’s mobile.

Read more:
Harry’s claim about William settling hacking case is awkward for Royal Family

Harry’s barrister David Sherborne has alleged the duke’s mother, Diana, Princess of Wales, had her calls and messages intercepted by NGN.

He claimed that articles taken from 1994 and 1995 demonstrated that NGN journalists and paparazzi working on their behalf “had inside knowledge” of where Diana was going to be.

And the phone calls of the King and Queen Consort were intercepted by the publisher of The Sun in the 1990s, the prince’s legal team alleges.

King Charles and the Queen Consort attending an Easter service at St George's Chapel in Windsor

Mr Sherborne alleged that NGN was intercepting phone calls and messages, as well as obtaining itemised phone bills of Charles and Camilla.

Articles allegedly published as a result between 1994 and 1995 include stories in The Sun from August 1995 with the headline “Heir to the Phone” and “The Midnight Caller”.

Earlier this week, Harry’s lawyers said Prince William settled a phone hacking claim against Rupert Murdoch’s UK newspaper group in 2020 for a “very large sum”.

NGN has previously settled a number of claims since the phone hacking scandal broke in relation to The News Of The World, which closed in 2011, but has consistently denied that any unlawful information gathering took place at The Sun.

Queen approved RAF repatriation jet for her coffin, saying: ‘If it’s good enough for my boys, it’s good enough for me’ – according to Mike Tindall | UK News

The Queen personally approved a plane to transport her coffin that had previously repatriated British soldiers’ bodies, reportedly saying: “If it’s good enough for my boys, it’s good enough for me.”

That’s the claim made by former England rugby union star Mike Tindall, who is married to the late monarch‘s eldest granddaughter Zara Tindall.

Before her state funeral on 19 August, Elizabeth II’s coffin was flown from Edinburgh Airport to RAF Northolt in west London on a RAF Globemaster C-17 aircraft, accompanied by the Princess Royal.

Mr Tindall described how the Queen’s original plane selection was substituted for the larger RAF aircraft to enable a more “dignified” ceremony.

Queen's coffin at Edinburgh airport. Pic: AP
Pic: AP

He said: “It wasn’t the original plane picked and they had to change it and they went for this big old plane to make it more dignified.”

Mr Tindall said he could not verify the story, sent to him by an “ex-army friend”.

And it appears the claims have been shared on social media after apparently being written by Pete Bond who says he was tasked, when a staff officer in 2009, with reviewing plans for the movement of the Queen’s coffin if she died overseas.

Mr Bond reportedly wrote that a BAE 146 business jet was due to transport the Queen, but access to its freight bay was difficult and it was substituted for the bigger C-17.

The Queen's coffin is carried aboard a RAF aircraft at Edinburgh airport

Mr Tindall claimed the Queen signed off the change of aircraft, used to repatriate the bodies of military personnel from Afghanistan, with the words: “If it’s good enough for my boys, it’s good enough for me.”

He added: “And that in itself just sort of sums it up.”

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Queen’s coffin departs Scotland

A senior RAF source said: “Extensive and comprehensive planning was conducted by the military for the demise of Her Majesty the Queen. The most appropriate assets were used throughout the operation.”

Mr Tindall told the story during The Good, The Bad & The Rugby podcast which he co-hosts.

When asked about the experience of the last few weeks, he replied: “It’s been sad, emotional but happy.”

Read more:
The Queen through the years – a life of service in pictures
Six moments that defined the Queen’s reign
The Queen’s most memorable quotes

Mike and Zara Tindall at the Queen's funeral in Westminster Abbey on 19 September
Mike and Zara Tindall at the Queen’s funeral in Westminster Abbey on 19 September

Asked to comment on the Queen’s death and her funeral, he replied: “In some ways amazing, in other ways to see the family come so close together – overnight.

“You never predict it, obviously (with) a 96-year-old lady, you know at some point it’s going to happen but you’re never ready for when it does.”

He added: “I’m not a direct family member in terms of blood but watching what my wife Zara had to go through, obviously she loved the Queen beyond everything else.”

The Rugby World Cup winner also spoke about his regrets, saying he wished he had quizzed the Queen about the history she had witnessed.

He said he had “loads of regrets about not asking her so many more things. Having nervousness when you have that lucky seat of being sat next to her”.