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First child to get new cancer treatment among 100,000 given early access to drugs in NHS milestone | UK News

Nearly 100,000 cancer patients have now had fast-track access to newly approved NHS drugs – with one teen saying his treatment felt like being on a “slope going up”.

Yuvan Thakkar, 16, was the first NHS patient to receive a therapy that uses the body’s own cells to fight cancer.

He was diagnosed with a form of leukaemia aged six and received the pioneering treatment at Great Ormand Street Hospital.

The CAR-T therapy, called tisagenlecleucel (Kymriah), involved removing his immune cells and modifying them to recognise and destroy cancer cells, before reintroducing them to the body.

In April, the NHS will have helped 100,000 patients access new and innovative treatments over eight years.

It’s been made possible by the NHS Cancer Drugs Fund – set up in 2016 to give patients faster access to new treatments.

The fund benefits people with common cancers, such as breast, lung, colorectal and prostate; as well as those with less common ones such as ovarian, cervical, kidney, and leukaemia – and also rare cancers including thyroid and biliary tract.

NHS England said patients get access to National Institute for Health and Care Excellence (NICE) approved treatments six months faster, and all cancer treatments are funded as soon as they are approved.

For Yuvan, who spent his childhood in hospital fighting leukaemia, faster access to the CAR-T therapy means he is now able to sit his GCSEs.

Recounting his treatment, he said: “I remember receiving the cells for a bit. I was feeling quite down” – before being sent to intensive care “where I couldn’t do basic counting and things like that”.

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The 16-year-old pictured with his family and (below) painting for his art GCSE

Painting for his art GCSE

The teenager said he doesn’t remember any of his treatment until it was finished.

“I thought I could start to get better, then I remembered, ‘oh, I can do this, I can do that’. And from now on, it’s just been like a slope going up,” said Yuvan.

Concern as cancer targets cut

Professor Sir Stephen Powis, the NHS England medical director, said treating 100,000 people was “a fantastic milestone”.

He said: “This vital fund is helping ensure patients get access to the most promising drugs far quicker than would otherwise be the case, helping people with cancer like Yuvan receive a life-changing intervention that sets a path for a longer, healthier life spent with family and friends”.

However, Professor Pat Price, a leading oncologist and co-founder of the Catch Up With Cancer campaign, is concerned about those still struggling to get treatment due to the backlog of cancer cases.

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Since the pandemic, she said 250,000 patients have not had their treatment on time.

National guidance states 85% of people should begin treatment within two months, or 62 days, of an urgent referral, but Professor Price said there has been a downgrade in ambition.

She told Sky News: “We are in the biggest cancer crisis we’ve ever had. This week the NHS have reset their targets for 2025 and sadly, they’ve pushed their recovery target for cancer.”

She said the target for next year had been cut from 85% to 70%.

Preventative cancer therapies can cause the disease to ‘hibernate’ and return later, research suggests | UK News

Preventative treatment designed to stop the recurrence of breast cancer can actually cause the cancer cells to mutate and ‘hibernate’, only to grow again years later, according to new findings.

Researchers who set out to explain why breast cancer can return years after initial treatment have found that hormone therapies used to prevent breast cancer from recurring, can trigger changes in some cells.

These changes cause the cells to lie dormant instead of dying off, and the cells “wake up” years later, causing a relapse that is harder to treat.

But the study has found there may be a way to target these “sleeping” breast cancer cells before they wake up, offering new hope for patients with oestrogen receptor positive (ER+) breast cancer – which makes up 80% of all breast cancers.

Luca Magnani, professor of epigenetic plasticity at The Institute of Cancer Research, London, said: “After surgery to remove primary oestrogen receptor positive breast cancer, patients are given five to 10 years of hormone therapy which aims to kill any remaining cancer cells.

“We know that this doesn’t work for all patients though, as their breast cancer can return years, or even decades later.

“We wanted to better understand why breast cancer does return so we can hopefully find ways to stop it – so people don’t have to live in fear or face the devastating news of a relapse.

“Our research identified a key mechanism used by cancer cells to evade therapy by remaining in a dormant state, hibernating before they ‘wake up’ years later and begin to rapidly divide again.”

The study, published in the journal Cancer Discovery, found that inhibiting an enzyme known as G9a prevented cancer cells from becoming dormant and killed the cells that were already hibernating.

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Dr Tayyaba Jiwani, science engagement manager at Cancer Research UK – which funded the research, said: “Breast cancer survival has doubled in the UK over the last 50 years thanks to better detection and screening, but there are still more than 11,000 deaths from this type of cancer every year.

“Although at an early stage, the findings reveal potential new targets for the development of innovative treatments that prevent breast cancer from coming back.”

Breast cancer is the second most common cause of cancer death among UK women, behind lung cancer, with around 11,400 deaths every year (2017-2019), Cancer Research UK said.

In 2022-23, almost 19,000 women across England were diagnosed with the disease thanks to the NHS screening programme.

Kate’s cancer diagnosis: Business as usual outside Windsor – despite a test of resilience for the royals | UK News

At Windsor this morning, crowds lined the streets to watch the Irish Guards pipe and drum their way into the castle grounds to change duties with the Welsh guards.

It was business as usual.

At Windsor this morning, crowds lined the streets to watch the Irish Guards pipe and drum their way into the castle grounds to change duties with the Welsh guards.
Image:
Crowds lined the streets to watch the Welsh guards change duties with the Irish Guards

The palace says constitutionally the same is true for the senior royals, even if there is a temporary changing of the guard.

The King is still holding audiences with dignitaries, but he has stepped back from public-facing engagements, and there is a sense of frailty in the royal household.

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Mbelwa Kairuki, High Commissioner for the United Republic of Tanzania, presents his credentials to King Charles III.
Pic: PA
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Mbelwa Kairuki, Tanzania’s high commissioner (right), with the King on Thursday. Pic: PA

Former press secretary to the late Queen, Ailsa Anderson, says: “This is not a crisis, it’s a bump in the road.”

But she added: “It’s very, very difficult obviously, and unsettling, because this is an institution based on stability and continuity, and you have two key players who are going to be out of action for some time.”

The late Queen had to step up her duties when her father was diagnosed with cancer in the late 1940s. The disease accelerated her accession to the throne when he died aged just 56.

She famously said: “I need to be seen to be believed.”

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Kate’s message: Diagnosis ‘came as huge shock’

How true that was of Princess Catherine – whose disappearance from the public eye sparked a frenzy of conspiracy theories.

And although she’s addressed those with her sobering reality, she won’t be back in the public gaze until medics say she’s fit to go.

For now, she can expect public curiosity has been replaced with sympathy, but clearly there is a lot on Prince William’s shoulders.

He will want to spend as much time as possible with Catherine and their three children, and will be with them at least for the Easter break.

But with his brother abroad and to some degree estranged, and his uncle Prince Andrew relieved of duties, there’s a dwindling pool of royal big-hitters available to hold the fort.

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Constitutional expert Craig Prescott said: “There has been a slimming down.

“There has been more emphasis on a small number of royals. So when two are out of action, that is perhaps a bigger issue.”

Constitutional expert Craig Prescott
Image:
Constitutional expert Craig Prescott

Queen Camilla has become a key player.

She delivered a speech written by the King on his behalf, on the Isle of Man this week, and next week she’ll play his role at the Maundy Thursday service in Worcester; a key royal fixture.

The remaining support team, Princess Anne, and the Duke and Duchess of Edinburgh are likely to have more focus on them too.

Queen Camilla meets members of the public during a visit to Belfast. Pic: PA
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The Queen meets members of the public during a visit to Belfast. Pic: PA

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Even Prince Andrew was leading the family at a recent memorial service in Windsor when William needed to be with Catherine.

This isn’t quite a crisis, but it is a test of resilience for the royals.

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They hope this is only a temporary situation, but what we’ve learned in recent weeks is that while they crave privacy in illness, the public craves information.

Finding that balance is just one of many challenges ahead.

Cancer cases on the rise despite fewer middle-aged people dying from the disease | UK News

Fewer middle-aged people are dying from cancer than at any point in 25 years, despite cases rising, according to new research.

A Cancer Research UK study found death rates among people aged between 35 and 69 have nosedived, thanks to screening, better treatment and fewer people smoking.

However, the Britain-wide study warned that improvements in survival are slowing down, while cancer cases are rising, with a 57% jump in men and a 48% jump in women over the quarter of a century studied.

In 1993, 55,014 cancer cases were registered in males, but this rose to 86,297 in 2018, while in women the rise was from 60,187 to 88,970.

Researchers said the rise was largely driven by increases in prostate and breast cancer, mostly due to better screening.

However, there were also “concerning” rises in melanoma, liver, oral and kidney cancers.

While cases are also rising due to population growth, obesity, drinking and inactivity are also playing a part, the researchers said.

Cancer Research UK claims that policies being brought in to combat smoking, obesity and alcohol, could prevent around 37,000 by 2040.

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Cancer survivor in favour of assisted dying

According to the study, four cancers (liver, melanoma, oral and kidney) showed “substantial increases in incidence” of more than 2% per year in both sexes across the period.

These are linked to lifestyle factors, such as alcohol, smoking, sun exposure and obesity, according to the study.

“Increases in liver cancer incidence and mortality for both men and women are very concerning, with nearly one in two attributable to modifiable risk factors,” they said.

“With high prevalence of overweight and obesity and diabetes in the general population, other studies expect the rates to remain high.”

Being overweight or obese can cause 13 types of cancer including stomach, bowel, liver, pancreatic, gallbladder, breast, uterus, ovary, kidney and thyroid.

Alcohol has been linked to seven types of cancer, including mouth, upper throat, larynx, oesophagus, breast and bowel cancer.

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The study found that, overall, death rates have dropped by 37% in men and by 33% in women over the 25 years, when accounting for the growing and ageing population.

Success against individual cancers is noted.

Deaths from cervical cancer fell by 54%, reflecting the success of NHS cervical screening and HPV vaccine programmes.

Lung cancer deaths also fell, by 53% in men and 21% in women, thanks to a fall in the number of smokers.

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UK ‘behind’ in cancer treatment

Drops were also observed for stomach, mesothelioma and bladder cancers in men, and stomach and non-Hodgkin lymphoma in women.

Cancer Research UK’s head of cancer intelligence and lead author of the study Jon Shelton said: “We must continue to prevent as many cancer cases as possible, diagnose cancers sooner and develop kinder treatments.”

“Cancer patients won’t feel the full benefits of advances in research breakthroughs and innovation, including new cancer treatments, without a long-term plan and funding from the UK government.”

Health Secretary Victoria Atkins said: “I welcome the positive findings of this report. Through innovations in technology and treatment, cancer screening programmes and measures to help people quit smoking, survival rates are improving across almost all types of cancer.”

For the study, researchers used UK-wide data to examine trends in men and women aged 35 to 69 who were newly diagnosed with, or died from, cancer between 1993 and 2018.

Sir Chris Hoy: Six-time Olympic gold medallist says he is being treated for cancer | Breaking News News

Six-time Olympic champion Sir Chris Hoy has announced he has been diagnosed with cancer.

The former track cyclist shared the news on his Instagram account, saying that he had hoped to keep the diagnosis private but that his “hand has been forced”.

Sir Chris said he was currently undergoing treatment, including chemotherapy, but added “I currently feel fine”.

The athlete’s full statement said: “I have a bit of news. Last year I was diagnosed with cancer, which came as a huge shock, having had no symptoms up to that point.

“I’m currently receiving treatment including chemotherapy, which thankfully is going really well. I’d like to extend my sincere gratitude to all the medical professionals for their amazing help and care.

“For the sake of my young family, I had hoped to keep this information private but regrettably our hand has been forced. Whilst I’m thankful for any support, I’d like to deal with this privately.

“My heart goes out to the many others who are also going through similar challenges right now.

“I’m optimistic, positive and surrounded by love for which I’m truly grateful. As you might imagine, the last few months have been incredibly difficult.

“However, I currently feel fine – I am continuing to work, ride my bike and live my life as normal.

“It’s an exciting year of work ahead, not least with the Paris Olympics in July. I can’t wait to get stuck in, have fun and share it with you all.”

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King Charles issues first message since cancer diagnosis | UK News

The King has made his first statement since being diagnosed with cancer, using it to give his “heartfelt thanks” to the public for their “comfort and encouragement”.

In a message, written from Sandringham in Norfolk, King Charles said: “I would like to express my most heartfelt thanks for the many messages of support and good wishes I have received in recent days.

“As all those who have been affected by cancer will know, such kind thoughts are the greatest comfort and encouragement.”

As well as thanking the public for their well wishes, the 75-year-old monarch also reflected on his decision to publicly reveal his illness, saying: “It is equally heartening to hear how sharing my own diagnosis has helped promote public understanding and shine a light on the work of all those organisations which support cancer patients and their families across the UK and wider world.”

Stressing his gratitude to the medical professionals and cancer charities, he added: “My lifelong admiration for their tireless care and dedication is all the greater as a result of my own personal experience.”

On Monday, Buckingham Palace announced the King had been diagnosed with a form of cancer while undergoing a procedure for an enlarged prostate.

In line with the initial announcement, the King in his new statement has not revealed any further details about what kind of cancer it is, the type of treatment he is having or what stage the cancer is at.

He started his treatment in London on Monday, and on Tuesday flew to Sandringham with the Queen.

It’s unclear when he may return to London, or if he’ll need to come back to the capital for his treatment.

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What next for the King?

The palace and the monarch had hoped that by being open about his cancer they could stop any potential rumours or speculation and allow the King to have some level of privacy while undergoing treatment.

In whatever ways they can they’ll be keen to offer reassurance that he remains capable of carrying out his constitutional duties.

This statement will be part of that strategy to show he remains positive. But they have made it clear they won’t be drawn into giving a running commentary about his condition.

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On Thursday, at an event at Salisbury Cathedral, the Queen spoke about her husband’s diagnosis for the first time, telling Ben Abbott, a critical care paramedic: “He is doing extremely well under the circumstances. He is very touched by all of the letters and messages the public have been sending from everywhere. That’s very cheering.”

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How prevalent is cancer in the UK?

During a speech at an Air Ambulance event on Wednesday night, Prince William also took time to thank everyone for their support both for his father and the Princess of Wales, who is recovering from abdominal surgery.

Other members of the Royal Family are now having to carry out the public engagements, with the monarch told not to do public-facing duties by doctors.

It makes a written statement from the King even more significant with it being his main way of communicating for now.

King Charles’s cancer diagnosis: What we know so far | UK News

The King has been diagnosed with a form of cancer, Buckingham Palace has announced.

The palace said the condition was discovered while the monarch was being treated in hospital for an enlarged prostate.

Here is what we know, and don’t know, so far – and what it could mean for the other royals.

What cancer does the King have?

The palace has not specified what form of the disease the King has, but they have said it isn’t prostate cancer.

They said during the monarch’s recent procedure for a benign prostate enlargement a “separate issue of concern” was noted.

Further diagnostic tests have identified “a form of cancer”.

Details of the type of test have not been divulged but diagnostic tests for cancer can involve blood tests, scans and biopsies.

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What do we know about the King’s diagnosis?

A biopsy is a medical procedure that involves taking a small sample so it can be examined under a microscope to identify whether there are abnormal cells present.

“No further details are being shared at this stage, but His Majesty is receiving expert care and looks forward to returning to full public duty as soon as possible,” a palace spokesperson said.

How is he being treated?

The King returned from Sandringham to London on Monday to start his treatment as an outpatient, meaning he will not have to stay in hospital.

“He remains at home in London this evening,” the palace said on Monday night.

It isn’t clear if he will be treated on the NHS or receiving private healthcare.

The monarch has begun a schedule of regular treatments and is said to be receiving expert medical care from a specialist team.

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Pic: PA
King Charles III and Queen Camilla leave after attending a Sunday church service at St Mary Magdalene Church in Sandringham, Norfolk
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Pic: PA


This could involve chemotherapy, a medicine used to kill cancer cells; radiotherapy, a treatment where radiation is used to kill cancer cells; or targeted drugs that find and attack cancer cells.

“His Majesty is grateful to his medical team for their expert care and swift intervention, is wholly positive about his treatment and looks forward to returning to full public duty as soon as possible,” the palace added.

How will diagnosis affect King’s work?

While the King receives treatment, it is understood he will still process state documents and hold his weekly audience with the prime minister.

However, the palace has confirmed “a number” of upcoming public engagements will be rearranged or postponed.

He has been advised by doctors to put off any public-facing plans.

“His Majesty would like to apologise to all those who may be disappointed or inconvenienced as a consequence,” the palace said, adding the Queen “will continue with a full programme of public duties”.

The monarch is also expected to remain available for meetings of the Privy Council, which usually meets monthly and is the oldest form of legislative assembly still functioning in the UK.

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What next for the King?

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He approves proclamations through this body, formal notices covering issues such as the summoning of a new Parliament and the dates of certain bank holidays.

It’s understood the details around how his duties will take place are yet to be confirmed.

The King’s role in general elections will also be a focus, as Rishi Sunak has hinted he will send the country to the polls in the second half of this year.

The monarch dissolves Parliament before a general election.

What could this mean for other royals – including Prince William and Prince Harry?

It’s possible that other working members of the Royal Family could take additional duties on behalf of the King, including Prince William.

The prince is currently helping the Princess of Wales recover from her surgery, but could take on more work once he is back to full public duty.

It’s understood the King personally told all his siblings and children he has cancer, and Harry has already confirmed he will head to the UK in the coming days.

The Queen is expected to support the King throughout his treatment alongside her full programme of duties.

King Charles apologises for postponed engagements after cancer diagnosis | UK News

The King has apologised for having to postpone engagements after his cancer diagnosis.

Buckingham Palace said the diagnosis means his forthcoming public engagements will have to be rearranged or postponed, as the Queen continues to attend to a full programme of public duties.

The King‘s diagnosis, announced on Monday, means it is unlikely he will attend the Commonwealth Day service at Westminster Abbey on 11 March.

The service is usually attended by senior members of the Royal Family.

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It was also expected the King and Queen would have several high-profile overseas visits over the coming months.

They were due to travel to Canada in May, and then to Australia, New Zealand and Samoa in October for the Commonwealth Heads of Government Meeting.

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Buckingham Palace is yet to confirm whether the tours – his first visits to those countries as King – will go ahead.

No date has been suggested for the King’s return to full public duties as he undergoes treatment.

The Palace has not officially confirmed any upcoming state visits.

“Regrettably, a number of The King’s forthcoming public engagements will have to be rearranged or postponed,” a Palace spokesperson said.

“His Majesty would like to apologise to all those who may be disappointed or inconvenienced as a consequence.”

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Other members of the Royal Family, including the Prince of Wales, may take on some extra duties on behalf of the King.

It is understood the King will continue to receive red boxes and have weekly audiences with the prime minister while undergoing treatment.

It is expected that alternative arrangements will be put in place for the weekly audiences should the King be advised by doctors to minimise in-person contact.

Bradley Lowery: West Bromwich Albion suspend fan over ‘disgusting’ tweet about cancer victim | UK News

A football supporter has been suspended by his club after an alleged “hateful” social media post about Sunderland fan Bradley Lowery was shared online.

West Bromwich Albion said in a statement they are “appalled” by the “disgusting” post.

The Championship club said it is helping police with their inquiries after hearing about a “hateful social media post referencing Bradley in the wake of the club’s defeat at the Stadium of Light on Saturday.

“Bradley was an inspirational young Sunderland fan who captured the heart of the nation as he bravely battled stage four high risk neuroblastoma – a rare form of childhood cancer – before his tragic passing, aged just six in, 2017,” read a club statement.

“Albion have identified and suspended the account of a supporter pending further legal inquiries and reserves the right to issue an indefinite club ban.

“The club are appalled by the disgusting post and offer their sincere apologies to Sunderland AFC and the Lowery family”.

Bradley Lowery, aged five, who is terminally ill with cancer, meets Sunderland's Jermain Defoe. Pic: Anna Gowthorpe/PA Archive
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Bradley Lowery with Sunderland’s Jermain Defoe. Pic: Anna Gowthorpe/PA Archive

The Bradley Lowery Foundation said on X it was “extremely sad that this keeps happening”.

Last month, a Sheffield Wednesday season ticket holder who mocked the boy’s death at a match, was given a suspended prison sentence and ordered to do 200 hours unpaid work.

A judge told Dale Houghton, 32, from Rotherham, his actions were “utterly appalling”.

Before he died, Bradley, who was a Sunderland mascot, was pictured with his favourite player, Jermain Defoe.

The striker spent time in hospital with Bradley and led out the England side with him for an international match.

More than half of people do not trust NHS to deliver timely cancer treatment – poll | Politics News

More than half of people have no faith they would receive timely treatment on the NHS if they were diagnosed with cancer, a poll has suggested.

The poll, by Savanta for the Liberal Democrats, also showed people are ignoring moles they think are cancerous and even attempting to remove lumps themselves because they think it will take too long to see a GP.

Liberal Democrat leader Sir Ed Davey said the results show the Conservatives have “broken people’s faith” in local services.

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Savanta asked 2,185 people how confident they were that they would be seen within a two-month timeframe if they were referred to a specialist for suspected cancer.

Some 40% said they were confident they would, but 52% were not confident and around 9% did not know.

People were also asked which of the following, if any, they had done because they thought it would take too long to be seen by a GP.

Some 21% said they had called NHS 111, 13% had ignored a lump or suspicious mole completely, 11% had self-diagnosed a lump or mole using the internet and 8% had gone straight to A and E with a lump or mole they thought could be cancerous.

Some 8% paid for private treatment to inspect a lump or mole and 7% had attempted to remove a mole on themselves or someone else.

Sir Ed said: “It’s shocking to see how badly people’s faith in their local health services has been broken by this Conservative government – to the extent that people are now putting their own health at risk by ignoring possible cancer symptoms.

“Early diagnosis and treatment of cancer is vital for improving someone’s survival, but these statistics show that some people have lost confidence that they will get it.”

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Sir Ed has promised to introduce a guarantee for cancer patients to begin treatment within two months if his party holds the balance of power after the next general election.

He has previously shared how he lost both parents at a young age to cancer.

The Lib Dems are looking to make major gains at the next election and have around 80 “blue-wall” seats in their sights where they came second to the Tories in 2019.

They have been focusing on the NHS as part of plans to woo Conservatives in the rural heartlands.

Prime Minister Rishi Sunak has made slashing waiting lists one of his five key priorities for government.

But the number of people in England waiting to start routine hospital treatment has continued to hit a record high.

An estimated 7.75 million people were waiting to start treatment at the end of August, the latest figures show, up from 7.68 million in July.

The data showed all cancer waiting time targets were missed.